Tunicamycin

Antibiotic. Protein glycosylation inhibitor.

Nucleoside antibiotic that inhibits protein glycosylation. Inhibits GlcNAc phosphotransferase (GPT) and inhibits the transfer of N-acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi and viruses.

> 98%

844.95

C₃₉H₆₄N₄O₁₆ (for tunicamycin C, n = 10)

11089-65-9

Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Soluble in DMSO to 50 mM

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Streptomyces sp.