ODS columns are the most popular columns and used for separations of hydrophobic compounds. The use of ion-pair reagents allows retention and separation of acidic or basic compounds on ODS columns. However, there are several problems associated with ion-pair reagents, for example, the lack of influence of ion-pair reagents on retention, the removal of ion-pair reagents retaind on the column, the use of LC-MS, etc. Hence, TCI developed and commercialised packing materials bearing both ODS ligands capable of firmly retaining hydrophobic compounds and ion-exchange ligands capable of retaining acidic or basic compounds in 1996.

■Target compound is basic → Choose ODS+Cation-Exchange Type
○TCI Dual ODS-CX10 （ODS+Strong Cation Exchange）
○TCI Dual ODS-CX15 （ODS+Medium cation Exchange）
○TCI Dual ODS-CX20 （ODS+Weak Cation Exchange）
Target compound is acidic → Choose ODS+Anion-Exchange Type
○TCI Dual ODS-AX10 （ODS+Strong Anion Exchange）
○TCI Dual ODS-AX20 （ODS+Weak Anion Exchange）
○Kaseisorb LC ODS-SAX （ODS+Strong Anion Exchange）
■Hydrophobic compounds can be retained on mixed-mode columns.
■No ion-pair reagent is required.
■The packing material has both ion-exchange and ODS phases.
（Not a mixture of packing materials of an ion-exchange and ODS）
■High NTP values close to ODS"s.

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